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Abstract #0801

Antibody Therapy Against Tau Pathology Improves Neuronal Transport as Assessed In Vivo by Tract-Tracing Manganese-Enhanced MRI

Maria F Baron1, Hameetha Banu Rajamohamed Sait2, Wajitha J RajaMohamed Sait 2, D Minh Hoang1, Einar M Sigurdsson2,3, and Youssef Z Wadghiri1

1Radiology, Center for Advanced Imaging Innovation & Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States, 2Neuroscience and Physiology, NYU School of Medicine, New York, NY, United States, 3Psychiatry, NYU School of Medicine, New York, NY, United States

Immunotherapies to target Alzheimer’s pathology have been developed in recent years. Amyloid‐ß centric approaches have shown limited efficacy, resulting in emphasis on immunotherapies for clearing pathological tau protein (τ-Thx). Our group has demonstrated that Tract‐Tracing Manganese Enhanced MRI (TT-MEMRI) is effective to monitor the deleterious effect of tau pathology on neuronal transport in transgenic (τ-Tg) mice. In this study, our TT-MEMRI protocol was used effectively to show the efficacy of acute tau antibody therapy in an advanced stage of tauopathy in the Tg model we previously characterized with TT-MEMRI. Specifically, neuronal transport can be restored after a four-week treatment period.

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