Abstract #0805

3D Amide-Proton-Transfer-Weighted (APTw) Image-Guided Stereotactic Biopsy in Patients with Newly Diagnosed Gliomas

Shanshan Jiang^1,2, Jaishri Blakeley³, Charles Eberhart⁴, Yi Zhang¹, Hye-Young Heo¹, Zhibo Wen², Lindsay Blair³, Huamin Qin ⁴, Michael Lim⁵, Alfredo Quinones-Hinojosa⁵, Dong-Hoon Lee¹, Xuna Zhao¹, Peter C.M. van Zijl¹, and Jinyuan Zhou¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Radiology, Southern Medical University Zhujiang Hospital, Guangzhou, China, People's Republic of, ³Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Pathology, Johns Hopkins University, Baltimore, MD, United States, ⁵Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States

We evaluated the accuracy of the APTw image-guided tissue biopsy via the neuro-navigation system in newly diagnosed gliomas. Patients (n = 24) with suspected gliomas of varying grades were recruited and scanned. APTw image-guided needle biopsy samples were obtained and analyzed histologically. Results showed that the APTw signal intensities were significantly higher in high-grade gliomas than in low-grade gliomas and that APTw signal intensities had a strong positive correlation with pathologic cellularity and proliferation. APTw image-guided biopsy in newly diagnosed gliomas has the potential to reduce the randomness of surgical decisions due to tumor heterogeneity.

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