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Abstract #0805

3D Amide-Proton-Transfer-Weighted (APTw) Image-Guided Stereotactic Biopsy in Patients with Newly Diagnosed Gliomas

Shanshan Jiang1,2, Jaishri Blakeley3, Charles Eberhart4, Yi Zhang1, Hye-Young Heo1, Zhibo Wen2, Lindsay Blair3, Huamin Qin 4, Michael Lim5, Alfredo Quinones-Hinojosa5, Dong-Hoon Lee1, Xuna Zhao1, Peter C.M. van Zijl1, and Jinyuan Zhou1

1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, Southern Medical University Zhujiang Hospital, Guangzhou, China, People's Republic of, 3Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 4Department of Pathology, Johns Hopkins University, Baltimore, MD, United States, 5Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States

We evaluated the accuracy of the APTw image-guided tissue biopsy via the neuro-navigation system in newly diagnosed gliomas. Patients (n = 24) with suspected gliomas of varying grades were recruited and scanned. APTw image-guided needle biopsy samples were obtained and analyzed histologically. Results showed that the APTw signal intensities were significantly higher in high-grade gliomas than in low-grade gliomas and that APTw signal intensities had a strong positive correlation with pathologic cellularity and proliferation. APTw image-guided biopsy in newly diagnosed gliomas has the potential to reduce the randomness of surgical decisions due to tumor heterogeneity.

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