Abstract #0806

Magnetic resonance imaging biomarkers for assessment of vascular pathologies in gliomas

Andreas Stadlbauer¹, Max Zimmermann¹, Karl Rössler¹, Stefan Oberndorfer², Arnd Dörfler³, Michael Buchfelder¹, and Gertraud Heinz⁴

¹Department of Neurosurgery, University of Erlangen, Erlangen, Germany, ²Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria, ³Department of Neuroradiology, University of Erlangen, Erlangen, Germany, ⁴Department of Radiology, University Clinic of St. Pölten, St. Pölten, Austria

Knowledge about the tumor microvasculature is important for monitoring of disease progression and treatment response. Forty-six patients with known or suspected brain tumors were examined using the vascular architecture mapping (VAM) technique. ΔR_2,GE versus (ΔR_2,SE)^3/2 diagrams were evaluated with new versions of microvessel radius (R_U) and density (N_U), which showed increased levels of heterogeneous structures in glioblastoma and meningioma. Three new imaging biomarkers were introduced: Microvessel type indicator (MTI), which allowed differentiation between supplying arterial and draining venous microvasculature. Vascular induced peak shift (VIPS), which is more sensitive to early angiogenic activity. Curvature was increased in peritumoral vasogenic edema.

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