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Abstract #0806

Magnetic resonance imaging biomarkers for assessment of vascular pathologies in gliomas

Andreas Stadlbauer1, Max Zimmermann1, Karl Rössler1, Stefan Oberndorfer2, Arnd Dörfler3, Michael Buchfelder1, and Gertraud Heinz4

1Department of Neurosurgery, University of Erlangen, Erlangen, Germany, 2Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria, 3Department of Neuroradiology, University of Erlangen, Erlangen, Germany, 4Department of Radiology, University Clinic of St. Pölten, St. Pölten, Austria

Knowledge about the tumor microvasculature is important for monitoring of disease progression and treatment response. Forty-six patients with known or suspected brain tumors were examined using the vascular architecture mapping (VAM) technique. ΔR2,GE versus (ΔR2,SE)3/2 diagrams were evaluated with new versions of microvessel radius (RU) and density (NU), which showed increased levels of heterogeneous structures in glioblastoma and meningioma. Three new imaging biomarkers were introduced: Microvessel type indicator (MTI), which allowed differentiation between supplying arterial and draining venous microvasculature. Vascular induced peak shift (VIPS), which is more sensitive to early angiogenic activity. Curvature was increased in peritumoral vasogenic edema.

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