Sau May Wong1, Jacobus F.A. Jansen1, C. Eleana Zhang2, Julie Staals2, Paul A.M. Hofman1, Joachim E. Wildberger1, Robert J. van Oostenbrugge2, Cécile R.L.P.N. Jeukens1, and Walter H. Backes1
1Radiology & Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 2Neurology, Maastricht University Medical Centre, Maastricht, Netherlands
Measuring subtle leakage through the
blood-brain barrier using DCE-MRI is challenging since their magnitude is lower
than in high-grade tumors. To have a clinical application, this method has to
be reproducible. The reproducibility of the transfer constant (Ki)
and fractional plasma volume (vp) using dual temporal
resolution DCE-MRI was investigated in 14 patients with cerebrovascular
disease. Low CVs and moderate to high ICCs demonstrate that despite
the noisy nature of the measurement, the method is moderately reproducible.
Still, cautious interpretation of the Ki and vp in individual patients is needed. Day-to-day
variations may be partly compensated by using session-averaged VIFs.