Abstract #0809

Measuring Subtle Leakage in Patients with Cerebrovascular Disease Using Dual Temporal Resolution DCE-MRI: Is it Reproducible?

Sau May Wong¹, Jacobus F.A. Jansen¹, C. Eleana Zhang², Julie Staals², Paul A.M. Hofman¹, Joachim E. Wildberger¹, Robert J. van Oostenbrugge², Cécile R.L.P.N. Jeukens¹, and Walter H. Backes¹

¹Radiology & Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, ²Neurology, Maastricht University Medical Centre, Maastricht, Netherlands

Measuring subtle leakage through the blood-brain barrier using DCE-MRI is challenging since their magnitude is lower than in high-grade tumors. To have a clinical application, this method has to be reproducible. The reproducibility of the transfer constant (K_i) and fractional plasma volume (v_p) using dual temporal resolution DCE-MRI was investigated in 14 patients with cerebrovascular disease. Low CVs and moderate to high ICCs demonstrate that despite the noisy nature of the measurement, the method is moderately reproducible. Still, cautious interpretation of the K_i and v_p in individual patients is needed. Day-to-day variations may be partly compensated by using session-averaged VIFs.

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