Abstract #0810

Modeling demyelination in white matter: the effect of realistic geometries on the susceptibility-weighted MR signal.

Tianyou Xu¹, Way Cherng Chen², Michiel Kleinnijenhuis¹, Sean Foxley¹, and Karla L Miller¹

¹University of Oxford, Oxford, United Kingdom, ²Singapore Bioimaging Consortium, Singapore, Singapore

Biophysical modeling of axons has conventionally assumed cylindrical geometries. In reality, axons vary in shape. Models consisting of circles benefit from simplicity, however the consequences of this assumption have not been studied. In this work, simulations incorporating realistic myelin shape derived from electron microscopy are employed to model white matter demyelination. Simulations are compared to a cohort of mice with varying levels of demyelination. Predictions from models that incorporate realistic myelin shape are in better agreement with experimental results in a mouse model of demyelination than those from circular models.

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