Meeting Banner
Abstract #0810

Modeling demyelination in white matter: the effect of realistic geometries on the susceptibility-weighted MR signal.

Tianyou Xu1, Way Cherng Chen2, Michiel Kleinnijenhuis1, Sean Foxley1, and Karla L Miller1

1University of Oxford, Oxford, United Kingdom, 2Singapore Bioimaging Consortium, Singapore, Singapore

Biophysical modeling of axons has conventionally assumed cylindrical geometries. In reality, axons vary in shape. Models consisting of circles benefit from simplicity, however the consequences of this assumption have not been studied. In this work, simulations incorporating realistic myelin shape derived from electron microscopy are employed to model white matter demyelination. Simulations are compared to a cohort of mice with varying levels of demyelination. Predictions from models that incorporate realistic myelin shape are in better agreement with experimental results in a mouse model of demyelination than those from circular models.

This abstract and the presentation materials are available to members only; a login is required.

Join Here