Abstract #0812

Functional Quantitative Susceptibility Mapping at 7-Tesla: Resolving Neuronal Activation Localized in Grey-Matter

Pinar Senay Özbay^1,2, Lars Kasper², Klaas Paul Pruessmann², and Daniel Nanz¹

¹Department of Radiology, University Hospital Zurich, Zurich, Switzerland, ²Institute of Biomedical Engineering, ETH Zurich, Zurich, Switzerland

Functional-QSM, promises to offer quantitative information more directly related to neuronal-activity than BOLD-fMRI and to partially ameliorate the inherent problem of spatial mismatch between locations of neuronal-activation and apparent BOLD-detected-activation. The data for fQSM and fMRI can be simultaneously acquired and mostly processed with the well-established fMRI toolchains. The current high-field study, evaluates details of the processing-chain, provides clear evidence that fQSM is capable (1) to detect neuronal-activation in well-resolved volumes that unambiguously reside within grey-matter, even after removal of apparent activations associated with larger-veins, and (2) to identify the visual-network in resting-state-experiments, thus highlighting a considerable potential of fQSM.

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