Abstract #0813

Assessing the (ani)sotropic component of R2 as a mean of studying White Matter properties

Rita Gil¹, Diana Khabipova^1,2, Marcel Zwiers¹, Tom Hilbert^3,4,5, Tobias Kober^3,4,5, and José P. Marques¹

¹Donders Institute, Radboud University, Nijmegen, Netherlands, ²Centre d'Imagerie BioMédicale, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ⁵LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

In this study we investigate the orientation dependence of transverse relaxivity (R₂) maps in white matter (WM) due to susceptibility effects of myelin microstructure. Subjects’ heads were rotated along different orientations with respect to B₀ and R₂ values (within different WM fibre populations) were decomposed into R₂ isotropic and anisotropic components (orientation independent and dependent respectively). Differences found in isotropic values were associated with fibres different diameter whereas differences found in anisotropic values were associated with the susceptibility effects from myelin. It was showed that the orientation of WM fibres influences R₂ contrast and coherence between hemispheres was also observed.

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