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Abstract #0813

Assessing the (ani)sotropic component of R2 as a mean of studying White Matter properties

Rita Gil1, Diana Khabipova1,2, Marcel Zwiers1, Tom Hilbert3,4,5, Tobias Kober3,4,5, and José P. Marques1

1Donders Institute, Radboud University, Nijmegen, Netherlands, 2Centre d'Imagerie BioMédicale, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 5LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

In this study we investigate the orientation dependence of transverse relaxivity (R2) maps in white matter (WM) due to susceptibility effects of myelin microstructure. Subjects’ heads were rotated along different orientations with respect to B0 and R2 values (within different WM fibre populations) were decomposed into R2 isotropic and anisotropic components (orientation independent and dependent respectively). Differences found in isotropic values were associated with fibres different diameter whereas differences found in anisotropic values were associated with the susceptibility effects from myelin. It was showed that the orientation of WM fibres influences R2 contrast and coherence between hemispheres was also observed.

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