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Abstract #0833

Study of Spatial Function in the Human Placenta with Diffusion Weighted Imaging

Edward Sutherland 1, Luís F Gonçalves1,2,3, and Yuxiang Zhou1,3

1William Beaumont Hospital School of Medicine, Oakland University, Rochester, MI, United States, 2Department of Obstetrics and Gynecology, Beaumont Health, Royal Oak, MI, United States, 3Diagnostic Radiology and Molecular Imaging, Beaumont Health, Royal Oak, MI, United States

Magnetic resonance diffusion weighted imaging (DWI) has been widely used to quantitatively measure the random motion of water molecules within a voxel of tissue and represents this information in the form of apparent diffusion coefficient (ADC) maps. As the ADC map has been shown to be influenced by circulatory motion and perfusion at low b-values, we hypothesize that ADC values obtained from the placenta may vary as a function of distance to the umbilical cord insertion. In this retrospective study, 78 healthy placentas were evaluated by MR-DWI. We conclude that ADC values of placental tissues obtained at high b-values do not vary in normal human placentas as a function of distance to umbilical cord insertion.

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