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Abstract #0834

Comparison of multi-component restricted and anisotropic models of diffusion in glandular breast tissue

Sisi Liang1, Narina Norddin2, Eleftheria Panagiotaki 3, Andre Bongers4, Peng Shi1, Laurence Gluch5, and Roger Bourne2

1College of Engineering and Science, Victoria University, Melbourne, Australia, 2Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, 3Center for Medical Image Computing, University College London, London, United Kingdom, 4Biological Resource Imaging Laboratory, University of New South Wales, Sydney, Australia, 5The Strathfield Breast Centre, Strathfield, Australia

DWI signal attenuation measured in biological tissue is widely observed to be non-monoexponential. One important diffusion characteristic underlying that complex behavior is restriction and hindrance to water diffusion. This study compared multi-component restricted and unrestricted models of diffusion in the glandular part of breast tissue. The results show that multi-component restricted and anisotropic models explain the data best. This finding is consistent with the presence of distinct diffusion microenvironments in breast tissue. Development of clinical DWI methods that incorporate these features may improve breast cancer assessment.

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