Abstract #0839

Hyperpolarized [1-13C]-Pyruvate Differentiates Distinctive Molecular Phenotypes in Diffuse Intrinsic Pontine Gliomas

Ilwoo Park¹, Rintaro Hashizume², Joanna Phillips^3,4, Sabine Mueller^3,5, and Sarah Nelson^1,6

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Neurological Surgery, Northwestern University, Chicago, IL, United States, ³Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, ⁴Pathology, University of California San Francisco, San Francisco, CA, United States, ⁵Pediatrics, University of California San Francisco, San Francisco, CA, United States, ⁶Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

Diffuse intrinsic pontine gliomas (DIPGs) are one of the most difficult pediatric cancers to treat. This study investigated the feasibility of ¹³C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized (HP) [1-¹³C]pyruvate for differentiating molecular characteristics of DIPGs. Differences in the lactate signal that were observed in two distinct biopsy-originated orthotopic DIPG tumors were associated with changes in the levels of LHDA and HIF-1α activity. This suggests that the non-invasive characterization of DIPGs using this new neuroimaging method may be helpful for assessing treatment response and tumor progression.

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