Abstract #0841

Differential Metabolism of Glucose and Acetate in Mitochondria of Early Stage Breast Cancer In Vivo

Elizabeth Maher¹, Kumar Pichumani², Venetia Sarode³, Tomoyuki Mashimo¹, Manoj Cheriyan¹, Vamsidhara Vemireddy¹, Barbara Haley¹, Dean Sherry², Roshni Rao⁴, Craig Malloy², and Robert Bachoo⁵

¹Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ³Pathology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Surgery, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, United States

Metabolic reprogramming of bioenergetic substrate utilization was shown in primary and metastatic brain tumors. Whether the use of substrates other than glucose to fuel the citric acid cycle is a property of cancer cell growth in the brain or a fundamental property of a transformed cell is not known. To address this question we studied early stage breast cancer patients using infusion of ¹³C-glucose or ¹³C-acetate during initial surgery. ¹³C-NMR spectra of resected tumors show that acetate but not glucose is oxidized in the citric acid cycle, suggesting that acetate may contribute to energy production in these early stage cancers.

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