Abstract #0842

Simultaneous imaging and 1H spectroscopy of small volume (1 µl) intracerebral microdialysate in healthy and glioblastoma-bearing rats using highly sensitive micro-coils

Silvia Rizzitelli¹, Stefan Glöggler¹, Noël Pinaud¹, Gerard Raffard¹, Veronique Bouchaud¹, Vanessa Zhendre¹, Stephane Sanchez¹, Alan Wong², and Yannick Cremillieux¹

¹Centre de Resonance Magnétique des Systemes Biologiques, University of Bordeaux, Bordeaux, France, ²NIMBE/LSDRM, CEA-Saclay, Gif-sur-Yvette, France

The challenge of this study was to investigate the ability of a custom-made 1H microsolenoidal coil operating at 7T, with an inner volume of 1 μL, of visualizing the on-line metabolism of brain metabolites through the use of a microdialysis catheter, carried out with the complementarity of MRI and MRS techniques. ¹H-MR spectra of in vitro (human gliobastoma cells) and in vivo (healthy and glioblastoma-bearing rats) were acquired every 3.50 minutes to monitor the real-time variations of metabolites concentration, after injection of ¹³C labelled compunds.

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