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Abstract #0842

Simultaneous imaging and 1H spectroscopy of small volume (1 µl) intracerebral microdialysate in healthy and glioblastoma-bearing rats using highly sensitive micro-coils

Silvia Rizzitelli1, Stefan Glöggler1, Noël Pinaud1, Gerard Raffard1, Veronique Bouchaud1, Vanessa Zhendre1, Stephane Sanchez1, Alan Wong2, and Yannick Cremillieux1

1Centre de Resonance Magnétique des Systemes Biologiques, University of Bordeaux, Bordeaux, France, 2NIMBE/LSDRM, CEA-Saclay, Gif-sur-Yvette, France

The challenge of this study was to investigate the ability of a custom-made 1H microsolenoidal coil operating at 7T, with an inner volume of 1 μL, of visualizing the on-line metabolism of brain metabolites through the use of a microdialysis catheter, carried out with the complementarity of MRI and MRS techniques. 1H-MR spectra of in vitro (human gliobastoma cells) and in vivo (healthy and glioblastoma-bearing rats) were acquired every 3.50 minutes to monitor the real-time variations of metabolites concentration, after injection of 13C labelled compunds.

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