Abstract #0845

Evaluation of nearby lymph nodes in a tumor mouse model by longitudinal MRI imaging at 11.7 Tesla.

María Jiménez-González¹, Sandra Plaza-García¹, Géraldine Pastor¹, and Torsten Reese¹

¹Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Spain

We developed a pancreatic tumor xenograft model in a nude mice to study characteristics of nearby lymph nodes. Using non invasive in vivo MR imaging at 11.7 Tesla, we monitored the tumor progression from 8 to 20 weeks. We observed enlarged lymph nodes in tumor bearing animals comparing to controls. Histological analysis demonstrated the presence of significant histiocytosis but not metastasis. Our study suggests that lymph node histiocytosis, in absence of functional adaptative immune system, plays a significant role of the innate immuno defense against cancer cells spreading.

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