Abstract #0846

Translating State-Of-The-Art Spinal Cord MRI Techniques To Clinical Use: A Systematic Review Of Clinical Studies Utilizing DTI, MT, MWF, MRS, and fMRI

Allan R. Martin¹, Izabela Aleksanderek¹, Julien Cohen-Adad², Zenovia Tarmohamed³, Lindsay Tetreault¹, Nathaniel Smith⁴, David W. Cadotte¹, Adrian Crawley⁵, Howard Ginsberg¹, David J. Mikulis⁵, and Michael G. Fehlings¹

¹Neurosurgery, University of Toronto, Toronto, ON, Canada, ²Electrical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ³Royal College of Surgeons Ireland, Dublin, Ireland, ⁴McMaster University, Hamilton, ON, Canada, ⁵Medical Imaging, University of Toronto, Toronto, ON, Canada

5 state-of-the-art spinal cord MRI techniques have been identified with great clinical potential. This systematic review finds trends in the technical methods employed and measures the progress of these techniques toward clinical translation. 104 studies were identified, with 69 DTI, 25 MT, 1 MWF, 11 MRS, and 8 fMRI studies. The DTI metric FA has the strongest evidence of utility, correlating with disability in numerous spinal conditions. Large, well-designed studies with a priori hypotheses, standardized acquisition methods, detailed clinical data collection, and robust automated analysis techniques are needed to fully demonstrate the potential of these rapidly evolving techniques.

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