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Abstract #0847

Combining biomechanical finite element analysis and multi-parametric MRI to assess mechanical and structural damage in cervical spondylotic myelopathy

Manuel Taso1,2,3,4, Pierre-Jean Arnoux2,4, Léo Fradet4,5, Arnaud Le Troter1,3, Jean-Philippe Ranjeva1,3,4, Kathia Chaumoître4,6, Pierre-Hugues Roche4,7, and Virginie Callot1,3,4

1CRMBM UMR 7339, Aix-Marseille Université, CNRS, Marseille, France, 2LBA UMR T 24, Aix-Marseille Université, IFSTTAR, Marseille, France, 3CEMEREM, AP-HM, Pôle d'imagerie médicale, Marseille, France, 4iLab-Spine international associate laboratory, Marseille/Montréal, France, 5Mechanical Engineering, Ecole Polytechnique de Montréal, Montréal, QC, Canada, 6Service de Radiologie, Hôpital Nord, AP-HM, Pôle d'imagerie médicale, Marseille, France, 7Service de Neurochirurgie, Hôpital Nord, AP-HM, Trauma Center, Marseille, France

While diagnosis of cervical spondylotic myelopathy is easily done with MRI, patient outcome is still difficult to predict. It is nonetheless associated to a strong mechanical cause as spinal cord’s (SC) compression is the first event leading to tissue alterations and neurological deficits. This work proposes an original approach using biomechanical numerical simulation, to apprehend the mechanisms of SC compression by the disk, and multi-parametric MRI, to probe the consequent microstructural alterations (axonal loss, demyelination …). Thanks to spatial normalization, first results on 3 patients are presented, allowing co-localization of personalized simulation of mechanical stress and structural MR alterations.

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