Abstract #0848

Application of APT CEST in Cervical Spinal Cord Normal Appearing White Matter of MS Patients at 3T

Samantha By^1,2, Alex K. Smith^1,2, Adrienne N. Dula^2,3, Bailey D. Lyttle², Siddharama Pawate⁴, and Seth A. Smith^2,3

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁴Neurology, Vanderbilt University, Nashville, TN, United States

Amide proton transfer (APT) CEST was applied to healthy and multiple sclerosis (MS) cohorts to determine its sensitivity to changes in normal appearing white matter in MS. Using a Lorentzian difference analysis, differences in the z-spectra of the MS and healthy cohorts around the APT frequency (Δω=+3.5 ppm) were observed. Significant differences in APT effect between MS and healthy controls were seen in the whole cord (p=0.0159), dorsal column (p=0.0159), and gray matter (p=0.0317). Lastly, a group-wise analysis highlights the ability to detect a decrease in mean APT effect in the MS cohort, despite the difficulty in detecting lesions in the anatomical.

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