Abstract #0848

Application of APT CEST in Cervical Spinal Cord Normal Appearing White Matter of MS Patients at 3T

Samantha By^1,2, Alex K. Smith^1,2, Adrienne N. Dula^2,3, Bailey D. Lyttle², Siddharama Pawate⁴, and Seth A. Smith^2,3

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁴Neurology, Vanderbilt University, Nashville, TN, United States

Amide proton transfer (APT) CEST was applied to healthy and multiple sclerosis (MS) cohorts to determine its sensitivity to changes in normal appearing white matter in MS. Using a Lorentzian difference analysis, differences in the z-spectra of the MS and healthy cohorts around the APT frequency (Δω=+3.5 ppm) were observed. Significant differences in APT effect between MS and healthy controls were seen in the whole cord (p=0.0159), dorsal column (p=0.0159), and gray matter (p=0.0317). Lastly, a group-wise analysis highlights the ability to detect a decrease in mean APT effect in the MS cohort, despite the difficulty in detecting lesions in the anatomical.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.