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Abstract #0856

Comparable glucoCEST and 2DG autoradiography measures of glucose metabolism in mild traumatic brain injury

Tsang-Wei Tu1, Wael Ibrahim1, Neekita Jikaria1, William Reid1, George Z. Papadakis1, Dima Hammoud 1, and Joseph A. Frank1

1Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States

The present glucose measurements from the brain are still insufficient to provide the essential spatial-temporal information. This study presents longitudinal glucose chemical exchange saturation transfer (glucoCEST) MRI to noninvasively detect the glucose metabolism in a rat model of mild traumatic brain injury (mTBI) and compares to the gold-standard 2-deoxyglucose (2DG) autoradiography. The current glucoCEST results parallel with 2DG-autoradiography results showing glucose uptake largely decreased after mTBI, that persisted over time. GlucoCEST is capable of delivering better image quality, higher image resolution and sensitivity to identify the potential window for effective treatments to increase the survival of injured brain.

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