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Abstract #0857

Cortical neurometabolic alterations induces anxiety-like behavior in rodent model of mild traumatic brain injury: A 1H-MRS and behavior study

Kavita Singh1, Seenu Haridas2, Kailash Manda2, Richa Trivedi1, and Subash Khushu1

1NMR, INMAS, DRDO, Delhi, Delhi, India, 2Neurobehavioral lab, INMAS, DRDO, Delhi, Delhi, India

Mild traumatic brain injury (mTBI), (70-90% of all TBI) shows consequences of anxiety-like behavioral alterations in approximately 23% of cases. The present study assesses acute anxiety-like behavior and its neurometabolic basis in a rodent model of mTBI using 1H-MRS and neurobehavioral analysis. At day5 reduced Tau/tCr levels in cortex was observed in mTBI group as compared to control. Neurobehavioral analysis showed increased anxiety-like behavior with normal cognition at day5. This study provides a putative neurometabolic basis of anxiety-like behavior in mTBI model which closely mimics human concussion injury.

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