Abstract #0857

Cortical neurometabolic alterations induces anxiety-like behavior in rodent model of mild traumatic brain injury: A 1H-MRS and behavior study

Kavita Singh¹, Seenu Haridas², Kailash Manda², Richa Trivedi¹, and Subash Khushu¹

¹NMR, INMAS, DRDO, Delhi, Delhi, India, ²Neurobehavioral lab, INMAS, DRDO, Delhi, Delhi, India

Mild traumatic brain injury (mTBI), (70-90% of all TBI) shows consequences of anxiety-like behavioral alterations in approximately 23% of cases. The present study assesses acute anxiety-like behavior and its neurometabolic basis in a rodent model of mTBI using 1H-MRS and neurobehavioral analysis. At day5 reduced Tau/tCr levels in cortex was observed in mTBI group as compared to control. Neurobehavioral analysis showed increased anxiety-like behavior with normal cognition at day5. This study provides a putative neurometabolic basis of anxiety-like behavior in mTBI model which closely mimics human concussion injury.

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