Abstract #0860

Mapping axonal injury distribution in mild traumatic brain injury with quantitative proton MR spectroscopy

Ivan Kirov^1,2, Matthew S. Davitz^1,2, Assaf Tal³, James S. Babb^1,2, Robert I Grossman^1,2, Yvonne W Lui^1,4, and Oded Gonen^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, ³Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ⁴Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, United States

Since axonal injury is a primary outcome of traumatic brain injury, our goal was to characterize its regional distribution from a metabolic perspective. We set out to identify regions prone to disproportionate injury, hence, candidate targets in potential clinical applications of proton MR spectroscopy (¹H-MRS). We found that metabolic axonal injury is diffusely distributed among commonly injured tracts, but multivoxel ¹H-MRS may lack sensitivity for its detection on a regional basis. These results motivate the use of ¹H-MRS approaches with higher sensitivity, such as global averaging, or large "single voxels" in areas of white matter, irrespective of placement location.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.