Abstract #0861

Proton MR spectroscopy identifies neuronal damage consistent with gray/white matter interface involvement in mild traumatic brain injury

Ivan Kirov^1,2, Matthew S. Davitz^1,2, Assaf Tal³, James S. Babb^1,2, Robert I Grossman^1,2, Yvonne W Lui^1,4, and Oded Gonen^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, ³Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ⁴Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, United States

Basic science studies have posited that the mechanical force associated with a traumatic brain injury disproportionately affects the interface between the brain’s gray and white matter (GM, WM); however, this has not yet been demonstrated in vivo. In this study we used multivoxel proton MR spectroscopy to compare metabolite levels of patients and controls in voxels with different GM and WM partial volume, on a continuum from “pure” GM to “pure” WM. The results indicate that the largest amount of damage lies within voxels representative of interface tissue.

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