Abstract #0862

Reduced Cortical and Thalamic Cerebral Blood Flow in Adolescents with Chronic Post-Concussive Symptoms

Samuel Barnes¹, Brenda Bartnik-Olson¹, Barbara Holshouser¹, and Stephen Ashwal²

¹Radiology, Loma Linda University, Loma Linda, CA, United States, ²Pediatric Neurology, Loma Linda University, Loma Linda, CA, United States

Several studies have shown regions of hypoperfusion in symptomatic patients in the chronic phase of mild TBI. In this study we used whole-brain spatial mapping and a voxel-wise statistical approach to investigate the extent and anatomical distribution of cerebral hypoperfusion in chronic symptomatic pediatric concussion subjects. Our findings identified multiple areas of reduced CBF, incorporating both the cerebral cortex and subcortical regions. Compared to our previous results using region of interest analysis, we detected a greater number of areas of hypoperfusion suggesting that the use of whole-brain spatial mapping and voxel-wise analysis improved detection of CBF abnormalities. We speculate that hypoperfusion in these regions may be implicated in cognitive deficits in these subjects.

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