Caroline Guglielmetti1,2, Austin Chou1, Annemie Van der Linden2, Susanna Rosi1, and Myriam M Chaumeil1
This study demonstrates that 13C MRS of
hyperpolarized pyruvate can be used to detect increased lactate production from
pro-inflammatory macrophages in a preclinical model of Traumatic Brain Injury,
hence providing a novel tool for in vivo
detection of neuroinflammation.