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Abstract #0863

Hyperpolarized 13C Metabolic imaging of neuroinflammation in Traumatic Brain Injury

Caroline Guglielmetti1,2, Austin Chou1, Annemie Van der Linden2, Susanna Rosi1, and Myriam M Chaumeil1

1University of California San Francisco, San Francisco, CA, United States, 2University of Antwerp, Antwerp, Belgium

This study demonstrates that 13C MRS of hyperpolarized pyruvate can be used to detect increased lactate production from pro-inflammatory macrophages in a preclinical model of Traumatic Brain Injury, hence providing a novel tool for in vivo detection of neuroinflammation.

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