Abstract #0864

Gauging the Effectiveness of Traumatic Brain Injury Treatment using MR Phase Gradient Mapping

Gregory Simchick^1,2, Martha Betancur^3,4, Lohitash Karumbaiah^3,4, and Qun Zhao^1,2

¹Physics, University of Georgia, Athens, GA, United States, ²Bio-Imaging Research Center, Athens, GA, United States, ³Animal and Dairy Science, University of Georgia, Athens, GA, United States, ⁴Regenerative Bioscience Center, Athens, GA, United States

Due to both short-term and long-term effects, traumatic brain injuries (TBIs) have been a growing topic of interest over the last several years; therefore, research related to the development of new methods to treat and monitor these types of injuries has also gained interest. Presented here is a non-invasive method using magnetic resonance (MR) phase gradient mapping (PGM) to characterize TBI treatment in relation to regional cerebral blood flow (rCBF) in angiogenesis and tissue loss. In a rat moderate-to-severe TBI model, increases between 16-29% in rCBF were seen in the treatment group twenty weeks post TBI, while decreases between 9-27% in rCBF were seen in the non-treatment group.

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