Kavita Singh1, Richa Trivedi1, Maria M D'souza2, and Subash Khushu1
1NMR, INMAS, DRDO, Delhi, Delhi, India, 2Molecular imaging, INMAS, DRDO, Delhi, Delhi, India
Hippocampal
atrophy is seen in traumatic brain injury even when it is remote to the site of
injury. Present study assess acute microstructural and inflammatory changes
affecting hippocampal damage using diffusion tensor imaging and Iba-1, GFAP immunostaining
at D0, 4H, D1 and D5 in rodent model of moderate TBI. Significantly reduced
mean diffusivity and radial diffusivity alongwith increased fractional anisotropy
at 4H, D1 and D5. Iba-1+ cells significantly increased at D1 and D5
with GFAP+ cells peaking at D5. Study provides temporal evaluation
of diffusion changes which may be due to underlying inflammatory changes.
