Abstract #0865

Evaluation of time-course of diffusivity changes and inflammatory response in hippocampus post moderate traumatic brain injury

Kavita Singh¹, Richa Trivedi¹, Maria M D'souza², and Subash Khushu¹

¹NMR, INMAS, DRDO, Delhi, Delhi, India, ²Molecular imaging, INMAS, DRDO, Delhi, Delhi, India

Hippocampal atrophy is seen in traumatic brain injury even when it is remote to the site of injury. Present study assess acute microstructural and inflammatory changes affecting hippocampal damage using diffusion tensor imaging and Iba-1, GFAP immunostaining at D0, 4H, D1 and D5 in rodent model of moderate TBI. Significantly reduced mean diffusivity and radial diffusivity alongwith increased fractional anisotropy at 4H, D1 and D5. Iba-1+ cells significantly increased at D1 and D5 with GFAP+ cells peaking at D5. Study provides temporal evaluation of diffusion changes which may be due to underlying inflammatory changes.

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