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Abstract #0888

Impact of Bicuspid Aortic Valve Fusion Phenotype and Valve Stenosis on Aortic 3D Hemodynamics: New Insights from a Large Cohort 4D Flow MRI Study in 312 subjects

Alex J Barker1, Pim van Ooij2, Emilie Bollache1, David Guzzardi3, S. Chris Malaisrie4, Patrick M McCarthy4, Jeremy D Collins1, James Carr1, Paul WM Fedak3, and Michael Markl1,5

1Radiology, Northwestern Univeristy, Chicago, IL, United States, 2Academic Medical Center, Amsterdam, Netherlands, 3University of Calgary, Calgary, AB, Canada, 4Cardiac Surgery, Northwestern Univeristy, Chicago, IL, United States, 5Bioengineering, Northwestern University, Chicago, IL, United States

Bicuspid aortic valve (BAV) morphology will alter transvalvular blood flow patterns and vessel wall shear stress (WSS). These hemodynamic changes have been associated with the regional expression of BAV aortopathy. However, the presence of aortic stenosis can confound the regional expression of WSS. The purpose of this study was to use aortic WSS atlases to understand the role of aortic valve morphology and stenosis on the expression of WSS in the ascending aorta of a large control and BAV patient cohort (n=312).

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