Abstract #0888

Impact of Bicuspid Aortic Valve Fusion Phenotype and Valve Stenosis on Aortic 3D Hemodynamics: New Insights from a Large Cohort 4D Flow MRI Study in 312 subjects

Alex J Barker¹, Pim van Ooij², Emilie Bollache¹, David Guzzardi³, S. Chris Malaisrie⁴, Patrick M McCarthy⁴, Jeremy D Collins¹, James Carr¹, Paul WM Fedak³, and Michael Markl^1,5

¹Radiology, Northwestern Univeristy, Chicago, IL, United States, ²Academic Medical Center, Amsterdam, Netherlands, ³University of Calgary, Calgary, AB, Canada, ⁴Cardiac Surgery, Northwestern Univeristy, Chicago, IL, United States, ⁵Bioengineering, Northwestern University, Chicago, IL, United States

Bicuspid aortic valve (BAV) morphology will alter transvalvular blood flow patterns and vessel wall shear stress (WSS). These hemodynamic changes have been associated with the regional expression of BAV aortopathy. However, the presence of aortic stenosis can confound the regional expression of WSS. The purpose of this study was to use aortic WSS atlases to understand the role of aortic valve morphology and stenosis on the expression of WSS in the ascending aorta of a large control and BAV patient cohort (n=312).

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