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Abstract #0893

Towards “non-invasive histology” of the brain by diffusion-weighted MR spectroscopy in vivo: comparison between diffusion-extracted synthetic cells and real histology in the mouse and primate brain

Marco Palombo1,2, Clémence Ligneul1,2, Chloé Najac1,2, Juliette Le Douce1,2, Julien Flament1,2, Carole Escartin1,2, Philippe Hantraye1,2, Emmanuel Brouillet1,2, Gilles Bonvento1,2, and Julien Valette1,2

1CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, 2CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France

A new diffusion-weighted MRS paradigm, combining advanced modeling with metabolites diffusion measurements at long diffusion times, is applied in the mouse and macaque brain in vivo. Resulting synthetic astrocytes and neurons (derived from cell-specific metabolite diffusion) can be compared with histological data. Very good agreement between Sholl analysis on real and synthetic astrocytes validates our approach and assumptions. We also measure increased size and complexity of synthetic astrocytes in primate compared to mouse, while dendritic organization appears better conserved throughout species. Although still in its infancy, our strategy opens new perspectives for the non-invasive evaluation of brain cell morphology.

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