Abstract #0892

CEST Imaging of the Serotonin Pathway

Rafal Janik¹, Lynsie A.M. Thomason², and Greg J. Stanisz^1,2,3

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Nerurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

A novel method for the detection of brain 5-HT, tryptophan, and 5-HIAA is presented. The method relies on the chemical exchange of an amide proton which is shifted outside the normal range for amide protons. This is demonstrate in-vivo in a rat model of 5-HT increase.

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