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Abstract #0892

CEST Imaging of the Serotonin Pathway

Rafal Janik1, Lynsie A.M. Thomason2, and Greg J. Stanisz1,2,3

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Nerurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

A novel method for the detection of brain 5-HT, tryptophan, and 5-HIAA is presented. The method relies on the chemical exchange of an amide proton which is shifted outside the normal range for amide protons. This is demonstrate in-vivo in a rat model of 5-HT increase.

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