Meeting Banner
Abstract #0891

Study of the Mutated Isocitrate Dehydrogenase 1 in Acute Myeloid Leukemia Using Hyperpolarized [1-13C]α-ketoglutaric Acid

Eugen Kubala1,2,3, Kim A. Muñoz Álvarez1, Oliver Dovey4, Steffen J. Glaser2, Markus Schwaiger1, George S. Vassiliou4, Roland Rad5,6, Rolf F. Schulte3, and Marion I. Menzel3

1Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany, 2Department of Chemistry, Technische Universität München, Munich, Germany, 3General Electric Global Research, Munich, Germany, 4The Welcome Trust Sanger Institute, Hinxton/Cambridge, United Kingdom, 5Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany, 6Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Munich, Germany

Previous studies suggest that isocitrate dehydrogenase 1 (IDH1) mutation plays a significant role in the cancerous metabolome. Among other alternations, expression of branched chain amino-acid transaminase 1 (BCAT1) is reduced, causing a decrease of α-ketoglutaric acid (αKG) to glutamic acid metabolic pathway. More importantly, the mutated IDH1 catalyzes a reaction of αKG to the oncometabolite 2-hydroxyglutarate. In this study we proved that these metabolic changes can be measured using hyperpolarized [1-13C]α-KG and 13Cmetabolic magnetic resonance spectroscopy (13CMMRS) in acute myeloid leukemia cell line in vitro.

This abstract and the presentation materials are available to members only; a login is required.

Join Here