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Abstract #0890

Metabolic profiling of in vivo brain rodent models by relaxation-enhanced 1H MRS of the downfield region at 21.1 T

Tangi Roussel1, Jens T. Rosenberg2, Samuel Colles Grant2,3, and Lucio Frydman1,2

1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, 3Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States

This study explores new opportunities that ultra-high field combined with non-water-suppressed 1H MRS methodologies make possible regarding the profiling of signals that resonate downfield from the water peak. Studies were carried out on rats using a 21.1-T ultra-widebore system, and focused on quantitatively analyzing the metabolic concentration changes for ischemic stroke and glioblastoma tissues. A general decrease in the relative metabolic concentrations were observed for both pathologies, certain molecules depart from this trend: lactate, glutathione (stroke), choline and UDP-Nacetyl hexosamines (glioma). Potential explanations for these features and new research avenues opened by these types of measurements are discussed.

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