Abstract #0890

Metabolic profiling of in vivo brain rodent models by relaxation-enhanced 1H MRS of the downfield region at 21.1 T

Tangi Roussel¹, Jens T. Rosenberg², Samuel Colles Grant^2,3, and Lucio Frydman^1,2

¹Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ²Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, ³Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States

This study explores new opportunities that ultra-high field combined with non-water-suppressed ¹H MRS methodologies make possible regarding the profiling of signals that resonate downfield from the water peak. Studies were carried out on rats using a 21.1-T ultra-widebore system, and focused on quantitatively analyzing the metabolic concentration changes for ischemic stroke and glioblastoma tissues. A general decrease in the relative metabolic concentrations were observed for both pathologies, certain molecules depart from this trend: lactate, glutathione (stroke), choline and UDP-Nacetyl hexosamines (glioma). Potential explanations for these features and new research avenues opened by these types of measurements are discussed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here