Abstract #0890

Metabolic profiling of in vivo brain rodent models by relaxation-enhanced 1H MRS of the downfield region at 21.1 T

Tangi Roussel¹, Jens T. Rosenberg², Samuel Colles Grant^2,3, and Lucio Frydman^1,2

¹Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ²Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, ³Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States

This study explores new opportunities that ultra-high field combined with non-water-suppressed ¹H MRS methodologies make possible regarding the profiling of signals that resonate downfield from the water peak. Studies were carried out on rats using a 21.1-T ultra-widebore system, and focused on quantitatively analyzing the metabolic concentration changes for ischemic stroke and glioblastoma tissues. A general decrease in the relative metabolic concentrations were observed for both pathologies, certain molecules depart from this trend: lactate, glutathione (stroke), choline and UDP-Nacetyl hexosamines (glioma). Potential explanations for these features and new research avenues opened by these types of measurements are discussed.

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