Abstract #0895

Vascular injury triggers a systemic response that promotes atherosclerosis progression at a remote site of injury.

Begona Lavin Plaza¹, Alkystis Phinikaridou¹, Marcelo Andia², Silvia Lorrio Gonzalez¹, and Rene Botnar¹

¹King's College London, London, United Kingdom, ²Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile

Atherothrombosis is a systemic arterial disease mainly involving the intima of large- and medium-sized arteries including the carotid, aorta, coronary, and peripheral arteries. Although it has long been known that atherosclerosis is a systemic disease, the effects of vascular alteration distally from the site of injury and the underlying mechanisms responsible for the systemic response have not been elucidated. In this study, we used an albumin-binding contrast agent to assess whether (1) vascular injury in the abdominal aorta triggers plaque progression in the brachiocephalic artery located distally to the site of injury and (2) whether neutrophils can be the link involved in this systemic response.

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