Abstract #0896

Translation of high-field fluorine-19 cell tracking techniques into the clinical realm

Jeff M Gaudet^1,2, Corby Fink^3,4, Matthew S Fox¹, Gregory A Dekaban^3,4, and Paula J Foster^1,2

¹Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Molecular Medicine, Robarts Research Institute, London, ON, Canada, ⁴Microbiology and Immunology, Western University, London, ON, Canada

Cellular MRI can be used to improve outcomes of cancer immunotherapy by tracking the fate of these cells after their administration. In this study, we used fluorine-19 MRI to track and quantify migration of antigen-presenting peripheral blood mononuclear cells (PBMC). Mice were imaged at both high-field and clinical field strengths. PBMC migration to the node was quantified and compared under different conditions. This study is the first to report on fluorine-19 imaging of PBMC and demonstrates the potential of cellular MRI to aid in the optimization of cellular therapy.

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