Mukundan Ragavan1, Xiaorong Fu2, Shawn C Burgess2, and Matthew E Merritt1
1Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States
In this study, the utility of sodium
propionate for accentuating changes in cardiac metabolism is evaluated. The
study is performed using a murine model of cardiac hypertrophy and employs
hyperpolarized magnetic resonance spectroscopy, mass spectrometry and a
biochemical assay to determine the cardiac redox state. Results show propionate
modulates cardiac metabolism across a range of different concentrations.