Abstract #0902

Tracking transplanted cells with paramagnetic fluorinated nanoemulsions

Alexander A. Kislukhin¹, Hongyan Xu¹, Stephen R. Adams², Kazim H. Narsinh¹, Roger Y. Tsien^2,3, and Eric T. Ahrens¹

¹Radiology, University of California San Diego, La Jolla, CA, United States, ²Chemistry & Biochemistry, University of California San Diego, La Jolla, CA, United States, ³Howard Hughes Medical Institute, La Jolla, CA, United States

Fluorine-19 magnetic resonance imaging (MRI) probes are used to label cells for quantitative in vivo tracking of cell therapies and visualizing inflammation. To reduce the ¹⁹F spin-lattice relaxation time (T₁) and enable rapid imaging and improved cell detection sensitivity, we prepared metal-binding fluorinated nanoemulsions, and then metalated them with a panel of transition and lanthanide ions. Iron(III) tris-β-diketonate PFPE nanoemulsion was observed to have superior MRI properties (¹⁹F T₁ as low as 6 ms). Overall, these agents can yield a multifold improvement in detection sensitivity over previously employed¹⁹F MRI methods to track transplanted cells.

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