Abstract #0903

Influence of Gender and Age on the Metabolic Profile of Blood Plasma in Celiac Disease Using Proton NMR Spectroscopy

Deepti Upadhyay¹, Uma Sharma¹, Govind Makharia ², Prasenjit Das³, Siddharth Datta Gupta³, and Naranamangalam R Jagannathan¹

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India, ³Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Metabonomics study on blood plasma of patients with Celiac disease (CeD) using NMR spectroscopy revealed gender and age specific variations. The concentrations of acetate, pyruvate, creatine and glycine were significantly higher in males with CeD compared to healthy males. While, levels of β-hydroxybutyrate, glycine and alanine were significantly elevated in females with CeD than healthy females. These metabolic differences indicated impairment in both catabolic and anabolic pathways of carbohydrate metabolism in CeD patients of both genders, however, fuel preference for energy requirement was gender specific, fatty acids were used in males while ketone bodies were preferred in females.

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