Deepti Upadhyay1, Uma Sharma1, Govind Makharia 2, Prasenjit Das3, Siddharth Datta Gupta3, and Naranamangalam R Jagannathan1
1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India, 3Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
Metabonomics study on blood plasma of
patients with Celiac disease (CeD) using NMR spectroscopy revealed gender and
age specific variations. The concentrations of acetate, pyruvate, creatine and
glycine were significantly higher in males with CeD compared to healthy males.
While, levels of β-hydroxybutyrate, glycine and alanine were significantly
elevated in females with CeD than healthy females. These metabolic differences
indicated impairment in both catabolic and anabolic pathways of carbohydrate
metabolism in CeD patients of both genders, however, fuel preference for energy
requirement was gender specific, fatty acids were used in males while ketone
bodies were preferred in females.