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Abstract #0905

Filtered serum-based metabolomics of prostate cancer using 1H NMR spectroscopy

Ashish Gupta1, Deepak Kumar1, Anil Mandhani2, and Satya Narain Sankhwar3

1metabolomics, Centre of Biomedical Research, Lucknow, India, 2Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, 3Urology, King George’s Medical University, Lucknow, India

To address the shortcomings of clinical indexes for the precise identification of prostate cancer (PC) and differentiation from benign prostatic hyperplasia (BPH) and healthy controls (HC), we applied 1H NMR spectroscopy as a surrogate tactic for probing of PC and BPH. The study comprises filtered sera from PC (n=75), BPH (n=70) and the HC (n=65). NMR-measured metabolites and clinical evaluation data were examined separately using multivariate discriminant function analysis (DFA) to probe the signature descriptors for each cohort. DFA reveals that filtered serum based metabolic profiling can differentiate not only HC from BPH and PC but also BPH from PC.

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