Sarah Calvert1, Steven Reynolds2, Martyn Paley2, and Allan Pacey1
1Department of Oncology & Metabolism, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom
is necessary for reproduction and low sperm motility can impede fertilization.
There is a need for greater understanding of the metabolic processes that drive
sperm motility. In this study, we examined differences in sperm metabolite
profiles between high and low quality sperm in order to identify possible intracellular
biomarkers of sperm quality and motility. Sperm motility was significantly
different between the two fractions and fell either side of the WHO lower
reference limit. Low quality sperm contained higher concentrations of choline,
methyls, citrate and lactate, indicative of increased cell membrane and altered
metabolism towards glycolysis.