Abstract #0907

Assessment of changes in metabolic profile of small intestinal mucosal biopsy of Celiac Disease patients after gluten-free diet: An in-vitro Proton NMR Spectroscopy study

Uma Sharma¹, Deepti Upadhyay¹, Govind Makharia², Siddharth Datta Gupta³, Prasenjit Das³, and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India, ³Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Present in vitro proton NMR study demonstrated the metabolic changes associated with villous abnormalities and its recovery following gluten free diet (GFD) in patients with Celiac disease (CeD). The concentration of glutamate and glutamine was significantly reduced in intestinal mucosa of CeD patients after GFD, indicating the use of these metabolites as oxidative fuels for energy generation. The level of glycerophosphocholine was significantly increased after GFD in CeD patients suggesting increased turnover of enterocytes essential for healing of intestinal mucosa in CeD patients. The results may have implications in determining the alternative biomarker/s for diagnosis and treatment management of CeD.

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