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Abstract #0924

Comparing Diffusion MRI with the Fiber Architecture and Tract Density of Gyral Blades

Kurt Schilling1, Vaibhav Janve1, Yurui Gao1, Iwona Stepniewska1, Bennett Landman1, and Adam Anderson1

1Vanderbilt University, Nashville, TN, United States

It has been reported that diffusion tractography has a tendency for streamlines to terminate preferentially on gyral crowns rather than on sulcal walls or fundi. Rather than anatomical reality, it has been suggested that this is a bias associated with tractography. To better understand this issue, we compare histology to diffusion MRI of the same specimen. We measure the trajectories and density of axons crossing the gray matter/white matter boundary and compare to diffusion tensor measures and deterministic tractography. The results of this study lead to a better understanding of gyral anatomy and potential limitations of fiber tractography.

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