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Abstract #0923

Neuroplasticity changes in rat brain following targeted irradiation assessed by diffusion MRI tractography validated by histology and behavioral tests

Julie Constanzo1, Matthieu Dumont2, Luc Tremblay1, Philippe Sarret3, Jean-Michel Longpré3, Karyn Kirby3, Sameh Geha4, Laurence Masson-Côté1, Benoit Paquette1, and Maxime Descoteaux2

1Nuclear Medicine and Radiobiology, Sherbrooke University, Sherbrooke, QC, Canada, 2Computing Science, Sherbrooke University, Sherbrooke, QC, Canada, 3Pharmacology and biophysics, Sherbrooke University, Sherbrooke, QC, Canada, 4Pathology, Sherbrooke University, Sherbrooke, QC, Canada

Despite its high efficiency for treating brain tumors and metastases, stereotactic radiosurgery (SRS) may lead to brain swelling, necrosis, and neuronal dysfunction, thus inducing delayed adverse effects such as cognitive decline and stroke-like symptoms. Altogether, our results revealed that SRS treatment induces region-specific plasticity (i.e. structural and function changes), as demonstrated by neuronal matrix remodeling using diffusion MRI and appropriate HARDI reconstruction, corresponding to histopathological modifications and changes in behavioral responses.

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