Abstract #0923

Neuroplasticity changes in rat brain following targeted irradiation assessed by diffusion MRI tractography validated by histology and behavioral tests

Julie Constanzo¹, Matthieu Dumont², Luc Tremblay¹, Philippe Sarret³, Jean-Michel Longpré³, Karyn Kirby³, Sameh Geha⁴, Laurence Masson-Côté¹, Benoit Paquette¹, and Maxime Descoteaux²

¹Nuclear Medicine and Radiobiology, Sherbrooke University, Sherbrooke, QC, Canada, ²Computing Science, Sherbrooke University, Sherbrooke, QC, Canada, ³Pharmacology and biophysics, Sherbrooke University, Sherbrooke, QC, Canada, ⁴Pathology, Sherbrooke University, Sherbrooke, QC, Canada

Despite its high efficiency for treating brain tumors and metastases, stereotactic radiosurgery (SRS) may lead to brain swelling, necrosis, and neuronal dysfunction, thus inducing delayed adverse effects such as cognitive decline and stroke-like symptoms. Altogether, our results revealed that SRS treatment induces region-specific plasticity (i.e. structural and function changes), as demonstrated by neuronal matrix remodeling using diffusion MRI and appropriate HARDI reconstruction, corresponding to histopathological modifications and changes in behavioral responses.

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