Abstract #0922

Validation of Diffusion Tensor MRI with Structure Tensor Synchrotron Imaging

Irvin Teh¹, Darryl McClymont¹, Marie-Christine Zdora^2,3, Valentina Davidoiu⁴, Hannah J Whittington¹, Christoph Rau², Irene Zanette², and Jürgen E Schneider¹

¹Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ²Diamond Light Source, Didcot, United Kingdom, ³Department of Physics and Astronomy, University College London, London, United Kingdom, ⁴Department of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Diffusion tensor imaging (DTI) is widely used to assess tissue microstructure, but is limited in resolution and cannot resolve multiple fibre populations within a voxel. Existing methods for validating DTI are limited in either resolution or coverage. 2D histological methods are additionally destructive and prone to tissue distortion. In contrast, synchrotron imaging strikes an excellent balance between resolution and coverage. Here, we demonstrate for the first time, the prospect of validating DTI with structure tensor analysis of synchrotron imaging data. Tensors reconstructed with DTI and structure tensor synchrotron imaging were consistent across the left ventricular wall of the heart.

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