Abstract #0921

Single MR spectral peak diffusion phantom with wide ADC range based on acetone, H2O and manganese chloride

Xiaoke Wang¹, Scott B Reeder^1,2,3,4,5, and Diego Hernando²

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Practical diffusion phantoms are urgently needed for technique development, protocol harmonization and quality assurance of quantitative diffusion MRI. Ideally, a diffusion phantom should have a single-peak NMR spectrum, Gaussian diffusion, with a wide range of tunable apparent diffusion coefficients (ADC). In this work, we developed and validated a novel diffusion phantom based on acetone-water mixtures doped with MnCl₂. This phantom exhibits the desired signal behavior, where water modulates the ADC of acetone, and MnCl₂ both eliminates water signal (through T2 shortening) and shortens the T1 of acetone.

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