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Abstract #0942

Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI at 3T

An T. Vu1,2, Alex Beckett1, Kawin Setompop3, and David A. Feinberg1,2

1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, United States, 2Advanced MRI Technologies, Sebastopol, CA, United States, 3Martinos Center for Biomedical Imaging, Charlestown, MA, United States

We evaluate the synergistic combination of super-resolution and SMS for high-resolution whole brain fMRI. We find that SLIDER-SMS can acquire high resolution, high CNR fMRI data at 3T which is normally only acquired at 7T. The regularized deblurring/reconstruction of SLIDER yielded 40% more BOLD CNR than normally acquired high resolution (HR) data, while omitting the deblurring step altogether yielded 100% more BOLD contrast with similar high k-space frequency tSNR. Future use of SLIDER for fMRI may enable robust columnar level results at 3T and allow higher spatial resolution fMRI investigations at 7T than currently possible.

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