Abstract #0942

Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI at 3T

An T. Vu^1,2, Alex Beckett¹, Kawin Setompop³, and David A. Feinberg^1,2

¹Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, United States, ²Advanced MRI Technologies, Sebastopol, CA, United States, ³Martinos Center for Biomedical Imaging, Charlestown, MA, United States

We evaluate the synergistic combination of super-resolution and SMS for high-resolution whole brain fMRI. We find that SLIDER-SMS can acquire high resolution, high CNR fMRI data at 3T which is normally only acquired at 7T. The regularized deblurring/reconstruction of SLIDER yielded 40% more BOLD CNR than normally acquired high resolution (HR) data, while omitting the deblurring step altogether yielded 100% more BOLD contrast with similar high k-space frequency tSNR. Future use of SLIDER for fMRI may enable robust columnar level results at 3T and allow higher spatial resolution fMRI investigations at 7T than currently possible.

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