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Abstract #0944

Blood volume fMRI with 3D-EPI-VASO: any benefits over SMS-VASO?

Laurentius Huber1, Dimo Ivanov2, Sean Marrett1, Puja Panwar1, Kamil Uludag2, Peter A Bandettini1, and Benedikt A Poser2

1Section of Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, United States, 2MBIC, Maastricht University, Maastricht, Netherlands

Cerebral blood volume (CBV) fMRI has the potential to overcome known limitations of BOLD fMRI with respect to spatial specificity and quantifiability of mapping brain activity. To overcome the coverage limitations of conventional CBV mapping with VASO, a novel VASO method with 3D-EPI readout was developed. This new approach is compared to BOLD fMRI and VASO with simultaneous multi-slice EPI readout. We provide evidence for a high sensitivity and improved specificity of 3D-EPI VASO compared to conventional BOLD fMRI. We conclude that because of its superior resolution in slice-direction, 3D-EPI VASO may play an important role in high-resolution fMRI.

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