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Abstract #0945

Optimization of Asymmetric Spin Echo Pulse Sequences in Functional MRI

Eun Soo Choi1 and Gary Glover2

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States

In BOLD contrasts fMRI, the most commonly used sequences, gradient-echo and spin-echo, have been challenged due to their limited spatial specificity or functional sensitivity. As an alternative, an asymmetric spin-echo sequence was introduced, yet, its characteristics in different conditions are still unclear. In this study, we performed simulations and in-vivo experiments to design the optimal ASE pulse sequence that maximizes functional sensitivity while preserving high spatial specificity.

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