1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States
contrasts fMRI, the most commonly used sequences, gradient-echo and spin-echo,
have been challenged due to their limited spatial specificity or functional
sensitivity. As an alternative, an asymmetric spin-echo sequence was introduced,
yet, its characteristics in different conditions are still unclear. In this study, we performed simulations and in-vivo experiments to design the
optimal ASE pulse sequence that maximizes functional sensitivity while
preserving high spatial specificity.