Abstract #0945

Optimization of Asymmetric Spin Echo Pulse Sequences in Functional MRI

Eun Soo Choi¹ and Gary Glover²

¹Electrical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States

In BOLD contrasts fMRI, the most commonly used sequences, gradient-echo and spin-echo, have been challenged due to their limited spatial specificity or functional sensitivity. As an alternative, an asymmetric spin-echo sequence was introduced, yet, its characteristics in different conditions are still unclear. In this study, we performed simulations and in-vivo experiments to design the optimal ASE pulse sequence that maximizes functional sensitivity while preserving high spatial specificity.

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