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Abstract #0953

Connectivity-based parcellation of nucleus accumbens into putative core and shell guiding for stereotactic target localization and alterations in each NAc subdivision in mTLE patients

Xixi Zhao1, Junling Wang1, Xiangliang Tan1, Xiang Xiao1, Zeyu Zheng1, Yingjie Mei2, Queenie Chan3, Yikai Xu1, Ru Yang4, and Qianjin Feng4

1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, 2Philips Healthcare, Guangzhou, China, People's Republic of, 3Philips Healthcare, HongKong, China, People's Republic of, 42School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, People's Republic of

NAc was supposed be involved in epileptogenesis, especially shell portion. The exact parcellation within the NAc and structural alterations in vivo of NAc subdivisions in EP patients remains unclear. We used diffusion probabilistic tractography to subdivide NAc into putative core shell subdivisions in individual mTLE patients for guiding NAc shell stereotactic target localization. Our results revealed that both left and right mTLE patients exhibited decreased FA and increased MD in shell portion of bilateral NAc, which may reflect neuronal degeneration and damage caused by seizure mainly in shell portions, and suggest a possible role of the NAc shell in epileptogenesis

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