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Abstract #0954

Brain White Matter Plasticity and Functional Reorganization Underlying the Central Pathogenesis of Idiopathic Trigeminal Neuralgia

Linying Guo1, Tian Tian1, and Wenzhen Zhu1

1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China, People's Republic of

Previous studies on trigeminal neuralgia (TN) have mainly focused on peripheral nerve damage, but little is known about the structural and functional changes in central nervous system (CNS) that can occur following trigeminal nerve dysfunction. In this study, we used diffusion kurtosis imaging (DKI) and functional connectivity density (FCD) mapping in TN patients to investigate both structural and functional changes in CNS. We found TN patients have correlated white matter and FCD reorganization that may contribute to pathologic algogenic system. Our findings may be helpful guidance for systematic therapeutics in both peripheral and central nerves.

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