Abstract #0955

Connectivity Domain Analysis of the Default Mode Network in Mild Traumatic Brain Injury at The Acute Stage

Armin Iraji¹, Natalie Wiseman², Robert Welch³, Brian O'Neil³, E. Mark Haacke^1,4, and Zhifeng Kou^1,4

¹Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ²Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States, ³Department of Emergency Medicine, Wayne State University, Detroit, MI, United States, ⁴Department of Radiology, Wayne State University, Detroit, MI, United States

Most functional and structural MRI studies in mild traumatic brain injury (mTBI) are performed at the group level. Recently, there is concern regarding the validity of group-level analyses findings in mTBI due to the heterogeneity of TBI. However, while group-level analysis cannot demonstrate a complete view of impairments, we hypothesize that there are similar patterns in group-level and subject-level findings, especially in higher order brain activities and networks. We evaluated this in the DMN using a new framework known as the connectivity domain. This is the first study of utilizing the connectivity domain to investigate changes after a brain disorder.

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