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Abstract #0959

High resolution 3D diffusion imaging of carotid vessel wall using stimulated echo based diffusion prepared turbo spin echo sequence

Qinwei Zhang1, Barbara Cervantes2, Dimitrios C. Karampinos2, Bram F. Coolen1, Aart J. Nederveen1, and Gustav J. Strijkers3

1Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Diagnostic and Interventional Radiology, Technische Universit√§t M√ľnchen, Munich, Germany, 3Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

Diffusion imaging is becoming a promising alternative to contrast enhanced imaging in detecting lipid core and hemorrhage in atherosclerotic plaques. Diffusion prepared turbo spin echo sequence (DP-TSE) has been proven to be feasible to acquire 3D diffusion images of carotid vessel wall, but it has critical requirement on the eddy currents. This study demonstrates that using stimulated echo based DP-TSE sequence, together with m1 nulling diffusion gradients, and MLEV refocusing RF pulses, high resolution 3D carotid vessel wall diffusion imaging can be achieved in the presence of eddy current, motion and B1-inhomogeneity.

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