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Abstract #0960

DCE-MRI reveals more extensive vasa vasorum in patients with cardiovascular events

Huijun Chen1, Juan Wang2, Jie Sun3, Daniel S Hippe3, Xihai Zhao1, and Hongbing Liu2

1Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, 2Cardiology, People’s Liberation Army General Hospital, Beijing, China, People's Republic of, 3Radiology, University of Washington, Seattle, WA, United States

Pharmacokinetic modeling of DCE-MRI can quantify the adventitial vasa vasorum of carotid atherosclerotic lesions using the transfer constant (Ktrans). However, the relationship between the DCE-MRI quantified carotid adventitial vasa vasorum and cardiovascular events remains unclear. In this study, we found that the adventitial Ktrans of carotid artery measured by DCE-MRI was associated with cardiovascular events (cerebral ischemic events and coronary artery events), suggesting that the carotid adventitial vasa vasorum is not merely a local risk factor but also a promising systemic marker for cardiovascular risk. DCE-MRI may be valuable for identifying high risk patients in clinical practice.

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