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Abstract #0965

Evaluation of endothelial barrier function in atherosclerosis induced rabbits using S-nitroso human serum albumin (S-NO-HSA) - blood pool agent compound and dynamic contrast-enhanced (DCE)-MRI

Peter Opriessnig1, Gunter Almer1, Harald Froehlich1, Claudia Cabella2, Rudolf Stollberger3, Seth Hallstroem4, Gerd Hoerl4, and Harald Mangge1

1Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria, 2CRB Bracco Imaging SpA, Colleretto Giacosa, Torino, Italy, 3Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 4Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria

Endothelial dysfunction plays a key role in the progression and pathogenesis of atherosclerosis (AS). DCE-MRI in combination with a special nitric oxide donor S-nitroso human serum albumin (S-NO-HAS) blood pool agent (B22956/1) compound could be an additional measure that provides information on the influence of plaque burden on the vascular permeability and vasomotion. In this work, we demonstrate the feasibility to investigate endothelial barrier function and NO induced endothelium-independent vasomotor response of the abdominal aorta in control and AS induced rabbits simultaneously. Relative vessel wall signal enhancement and change in lumen area were measured using a double-inversion-recovery turbo-spin-echo sequence.

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